Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene
نویسندگان
چکیده
منابع مشابه
Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.
Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is less lipidated than its corresponding AD-benign form, apoE3, and it has been suggested that the pathological effects of apoE4 are mediated by lipid-related mechanisms. ATP-binding cassette transporters A1 and G1 (ABCA1 and ABCG1, respectively) are the most important apoE-lipidating proteins. The e...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2014
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.5198-13.2014